585+ 2021 Mercedes-Benz E450 Parts

Which trim do you have?

Brakes, exhaust, wheels, and suspension can vary by trim. Picking yours means we only show what actually fits — mats, wipers, and covers show regardless.

What do you want for your vehicle?

Start with an intent — drill into any category for exact-fit picks.

Keep it running

Maintenance & repair

NTK ABS Wheel Speed Sensor

Quality-Built Premium Ceramic Brake Pads w/ Hardware

BRAKE DISC (PR-EA/BX-2)

Mobil 1 V-Twin 20W-50 Synthetic Motorcycle Oil (1 Quart)

Browse all categories

Every category we carry for this vehicle, organized by system.

Maintenance & fluids

Brakes & suspension

Interior

Exterior

Car Covers(9)

Towing & off-road

Cargo & Racks(11)

Maintenance & Repair Jobs

Find all the parts you need for common jobs on your 2021 Mercedes-Benz E450.

Brake Job Oil Change Tune-Up Suspension Upgrade Wiper Replacement Battery Replacement

Frequently Asked Questions

Do these parts fit my 2021 Mercedes-Benz E450?

This page groups parts listed for the 2021 Mercedes-Benz E450. Some products fit every trim, while others depend on submodel, engine, drivetrain, or brake package. Use your trim in My Garage or the product page fitment check to confirm exact fit.

What are the most popular parts for the 2021 Mercedes-Benz E450?

The most popular categories for the 2021 Mercedes-Benz E450 include Control Arms & Bushings, Oil & Fluids, Brake Pads, and Floor Mats & Liners. Browse our full selection to find the exact parts you need for your vehicle.

How fast do 2021 Mercedes-Benz E450 parts ship?

Most in-stock items ship within 1-2 business days. Shipping rates are calculated at checkout based on your location.

What warranty do your 2021 Mercedes-Benz E450 parts come with?

Warranty coverage varies by manufacturer but typically ranges from 1 year to lifetime. Each product page includes specific warranty information from the manufacturer.