Choose your trim in My Garage to confirm exact fit.
Exact-fit parts for the 2010 GMC Sierra 2500 HD SLE.


Dorman
Part # 300-826
$304.20
aFe
Part # 46-52041
$1042.88


Dorman
Part # 902-2127
$76.07


Elring
Part # 868.630
$8.93


Delphi
Part # TS10076
$23.96


Four Seasons
Part # 92017
$44.43


Dayco
Part # 87959
$51.49

Sunsong
Part # 3404848
$40.59
aFe
Part # 46-52161
$783.97

Mishimoto
Part # MMHOSE-CHV-06DRD
$389.07


Gates
Part # 28410
$70.13

Motorad
Part # 2523-160
$20.81


Standard Motor Products
Part # S-1288
$28.44


NGK
Part # EF0155
$17.47

Sunsong
Part # 3402199
$32.13


Four Seasons
Part # 37537
$49.10

BD Diesel
Part # 1030606-5/8
$799.99

Collision
Part # GM1225320
$36.77


Dorman
Part # 800-409HP
$24.03


Delphi
Part # TS10253
$30.07
This page groups parts listed for the 2010 GMC Sierra 2500 HD SLE. Some products fit every trim, while others depend on submodel, engine, drivetrain, or brake package. Use your trim in My Garage or the product page fitment check to confirm exact fit.
We offer a wide selection of cooling system parts for the 2010 GMC Sierra 2500 HD SLE. This page narrows the catalog to the year, make, and model; use your trim on product pages to confirm exact fit when a part only fits certain submodels.
We carry parts from trusted brands including Wehrli, Dorman, Gates, Four Seasons, and Motorad, plus many more. Filter by brand to find your preferred manufacturer.
Most in-stock items ship within 1-2 business days. Shipping rates are calculated at checkout based on your location.
Warranty coverage varies by manufacturer but typically ranges from 1 year to lifetime. Each product page includes specific warranty information from the manufacturer.